9/10/2023 0 Comments Jing chen emory![]() ![]() Lin observed that the enzyme chondroitin sulfate glucuronyltransferase (CSGlcA-T, or CSG here for short) emerged in her screen. Working with Chen, instructor Ruiting Lin discovered the effect while evaluating various metabolic enzymes for whether they would be necessary to drive proliferation in mutated B-raf melanoma. He adds that a large study from the state of Washington showed no link between chondroitin sulfate and prostate or lung cancer risk, although the work did not examine genetic background, which might influence individual cancer risk. We found that we had to add a line to the forms melanoma patients fill out about their histories, since we weren’t asking before.” Calcium supplements may damage the heart “There is not a lot of hard data on dietary supplement use. “We want to be cautious about these results, and they should be followed up,” he says. It is possible that someone with precancerous lesions containing the V600E mutation, who takes chondroitin sulfate, might accelerate the growth of those cells, or that V600E positive cancer patients taking chondroitin sulfate might have a higher risk of relapse, says Chen, professor of hematology and medical oncology at Winship Cancer Institute of Emory University. Chondroitin sulfate, a structural component of cartilage, is often recommended for the treatment of osteoarthritis, in combination with other compounds such as glucosamine. While unconfirmed in human epidemiological studies, the findings are a warning to oncologists, and to people at an elevated risk of melanoma, regarding potential risks of dietary supplements. V600E tumors in mice fed with chondroitin sulfate also showed resistance to vemurafenib, a small molecule B-raf inhibitor currently used to treat V600E-positive melanoma patients. “There is not a lot of hard data on dietary supplement use.”Ĭhondroitin sulfate, given to mice with implanted V600E tumors, has a similar effect at levels comparable to those seen in humans when it is used as a dietary supplement. Jing Chen and colleagues found that chondroitin sulfate can boost growth by melanoma cells carrying the V600E mutation, but not other melanoma cells. ![]() One particular mutation in the B-raf gene (V600E) can be found in about half of melanomas. Chondroitin sulfate, a dietary supplement for strengthening joints, can speed the growth of a type of melanoma, according to experiments conducted in cell culture and mouse models.
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